Journal article
Adipose Tissue Exosomal Proteomic Profile Reveals a Role on Placenta Glucose Metabolism in Gestational Diabetes Mellitus
N Jayabalan, A Lai, V Ormazabal, S Adam, D Guanzon, C Palma, K Scholz-Romero, R Lim, T Jansson, HD Mcintyre, M Lappas, C Salomon
Journal of Clinical Endocrinology and Metabolism | Published : 2019
Abstract
Context: Molecules produced by adipose tissue (AT) function as an endocrine link between maternal AT and fetal growth by regulating placental function in normal women and women with gestational diabetes mellitus (GDM). Objective: We hypothesized that AT-derived exosomes (exo-AT) from women with GDM would carry a specific set of proteins that influences glucose metabolism in the placenta. Design: Exosomes were isolated from omental AT-conditioned media from normal glucose tolerant (NGT) pregnant women (n = 65) and pregnant women with GDM (n = 82). Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry was used to construct a small ion library from AT and exoso..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The present study was supported by the Lions Medical Research Foundation, University of Queensland, Faculty of Medicine M+BS Emerging Leaders Medical Research Grant, National Health and Medical Research Council (grant 1114013), Diabetes Australia (grant Y18G-SALC), and Fondo Nacional deDesarrollo Cientifico y Tecnologico (grant 1170809). M.L. is supported by a Career Development Fellowship from the National Health and Medical Research Council (grant 1047025) and a Research Fellowship from the University of Melbourne. N.J. holds a scholarship from the Public Service Department of the Malaysian Government.